ASHM Report Back

Clinical posts from members and guests of the Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine (ASHM) from various international medical and scientific conferences on HIV, AIDS, viral hepatitis, and sexual health.

Increasing Cardiovascular Disease Incidence in HIV Positive Adults in Asia – Projections for 2017 – 2026

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The Talk was by Rimke Bijker who is a PhD Student from The Kirby Institute. 

As aging population with HIV positive in Asian countries, risk of increasing trend of Cardiovascular Disease is unavoidable. Overtime, about 60 % of patients (HIV Positive) will be aged over 40 years in 2025.

Risk of  Cardiovascular Disease (CVD)comprises traditional risk factors as well as specific factors

- Traditional risk factors comprises dyslipidaemia, diabetes status, hypertension and also smoking

Specific factor such as high Viral Load count, Low CD 4 count 

There is an ongoing research Over 10 - year period at Asian region, which included 20 clinical sites, 12 countries and some part of South East Asia 

The cohort data base was used from TAHOD ( Treat Asia HIV Observational Database ) was established in September 2003

 

This based on Gender, Age, ART regimen, status of Diabetes Mellitus 

Assumptions

- Patient remains on current anti retro viral therapy 

- Stopped Abacavir ( ABC ) < 6 months ago 

- No Family history of  CVD data, based on prevelance of the same population

Clinical Data

Total number of study - 3406, comprises ;Male 69 % and Female 32 %, > 50 age  29 %

Hetero 68 % Homo 29 %

Projections

– increasing trend doubled of risk of Diabetes in 2026 compared with 2017, ( almost 1500 events in 2026 )

- Global data for burden – 900 events, although throughtout the period the same for 2026

 

Subgroups of outcome 

-          Male > female

-          Age > 50 higher than younger

-          Income does not change the outcome 

-          DM > than no DM

-          Protease Inhibitors  > no Protease Inhibitor Regime 

Limitations of Study

-Critique on risk scores

-Generalisablity

-Risk score Based on mostly European population 

Take Home Message 

There will be doubling of CVD events in a decade time. Therefore, Primary physicians / health care professionals need screening for those population

 Age as Older patients, having Diabetes and also taking PI Regimen are high risk of having CVD events 

There is no conflict of interest for this study 

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