ASHM Report Back

Clinical posts from members and guests of the Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine (ASHM) from various international medical and scientific conferences on HIV, AIDS, viral hepatitis, and sexual health.

Maraviroc and treatment intensification

Posted by on in New ARV Treatment, clinical trials emerging therapy
  • Font size: Larger Smaller
  • Hits: 993
  • Print

Is there a role for treatment intensification with Maraviroc in addition to a standard cART for naïve patients with low CD4 counts, and will it decrease the risk of progression to AIDS? (ANRS 146 – GeSIDA OPTIMAL)

There is no clinical evidence that of successful treatment intensification by the addition of a 4th antiretroviral agent; despite numerous trials.

This double-blinded trial in France , Italy and Spain compared Maraviroc (+cART) to placebo (+cART).   Over 400 naïve, HIV-1 infected patients with an AIDS defining illness or CD4 cells < 200cell/mm^3 were enrolled.

The primary endpoint was the occurrence of a severe morbidity (AIDS, SNAE, IRIS, Death or other HIV related disease). Baseline characteristics were comparable.

In the 72-week follow up period; treatment intensification made no impact on the risk of infections, serious events, mortality, virilogic control or on CD4 count recovery. A post hoc analysis suggested Maraviroc might demonstate benefit on the occurrence of clinical events in the first 6 months of treatment, however this benefit “subsequently disappeared”.

Tagged in: 2017 IAS Conference
  • No comments made yet. Be the first to submit a comment

Leave your comment

Guest
Guest Friday, 18 October 2019

RT @SWOPnsw: "New Australia-first research into the experiences of trans and gender diverse people in the health system, including cancer c…

ASHM ASHM

RT @KirbyInstitute: “Health systems must meet the specific sexual health needs of gender-diverse communities. Not adequately accounting for…

ASHM ASHM

RT @thisnewman: I was recently reminded I had made an assumption about the pronouns of a new GP, as I hadn't thought to ask, and never have…

ASHM ASHM