ASHM Report Back

Clinical posts from members and guests of the Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine (ASHM) from various international medical and scientific conferences on HIV, AIDS, viral hepatitis, and sexual health.

Hepatitis B vax - 3 is enough

  • Font size: Larger Smaller
  • Hits: 3129
  • Print

Chaiklang et al conducted a randomized trial in Thailand, in 132 HIV+ adults who were HBV– and had CD4 cell count of >200 cells/μL and undetectable viral load of 3 different hepatitis B vaccine schedules.


Patients were 1:1:1 randomly assigned to receive a standard vaccination (20 μg intramuscularly at month 0, 1, and 6 or 20 μg IM at month 0, 1, 2, and 6 or 40 μg IM at month 0, 1, 2, and 6. .Responders were patients who had hepatitis B surface antibody (anti-HBs) of at least 10 mIU/mL) at month 7.


The percentage of responders at month 7 was 88.6 in the IM 20x3 group, 93.2 in the IM 20x4 group (p = 0.458 vs IM 20x3 group), and 95.5% in the IM 40x4 group (p = 0.237 vs IM 20x3 group).


The standard HBV vaccination in HIV+ adults with CD4 cell counts >200 cells/μL and undetectable viral load is highly effective. Regimens of 4 injections of either standard or double doses may increase the response rate and induce higher level of protective antibody.

Tagged in: CROI2012
  • No comments made yet. Be the first to submit a comment

Leave your comment

Guest
Guest Tuesday, 23 July 2019

RT @GregDore2: Crucial to continue the momentum of GP care for people with #HCV. In 🇦🇺 more than 6,000 GPs have prescribed DAA therapy sinc…

ASHM ASHM

RT @WHO: In 1991 the #HIV movement was branded with the iconic red ribbon. New York-based artists from the @Visual_AIDS Artists' Caucus cre…

ASHM ASHM