Quarraisha and Salim Abdool Karim opened with the N'Galy- Mann lecture. Their talks chronicled 20+ years of HIV research and epidemiology in Africa.
The CAPRISA 004 study into tenofavir gel used vaginally to prevent transmission was discussed. Salim gave a particularly interesting review of the analyses they did into why the results were not better. Adherence of >80% was associated with better protection, but concurrent genital inflamation, resulting in increased cytokine involvement in the vaginal region, was associated with a 14 times greater risk of HIV Infection. The whole presentation which went into a number of other issues will be avaiable on the CROI site soon, but the take home message from this was the importance of STI screening and the impact that STI s can have on priming HIV binding sites.