@paulkidd Fantastic news + congrats 👏🏾👏🏾👏🏾
The short answer from Jeffery Klausner (UCLA, CA) is; Yes.
Jeffery spoke about the two studies and looked at those results.
Antibiotic prevention is nothing new; Rheumatic fever, travellers (Malaria), Lyme Disease, or Travellers Diarrhoea.
With increasing Syphilis rates in MSM and the risk of facilitating HIV transmission, Doxycycline Prophylaxis could defiantly have a place.
As we already know, Doxycycline is a narrow spectrum antibiotic that is inexpensive.
Two RCT's were conducted; one study looked at daily 100mg Doxycycline for 30 men over 48 weeks (not behavioural intervention), on average most had 1mg/ml in samples with only a few having undetectable levels (?non adherence) which overall showed good levels.
- 73% reduction in Syphillis
- 70% reduction in other STI's (Chlamydia)
Study 2: On demand Doxycycline as PEP. RCT in HIV negative men on 200mg single dose up 24 hours after sex, maximum 72 hours post sex. NB: No more than six pills per week.
- 70-73% reduction in Syphilis and Chlamydia infections.
- No effect on Gonorrhoea.
- Noted increase in GI side effects, (nausea, GI pain and vomiting), nil adverse events.
Both studies showed great results, but more research needs to be done (Australia is part of a trial at the moment), and concerns around long term safety as well as ?Resistance (MRSA) were raised.
Overall a great presentation looking at the future of condomless prevention of STI's in a time where we have over 6000 MSM using condomless HIV prevention in NSW (EPIC, NSW)